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Featured research · Anesthesia & Analgesia · 2026

Beyond the Anesthesia Machine: The Hidden Carbon Cost of Nitrous Oxide

Explore the evidence behind central N₂O pipeline deactivation, clinical decision support, and anesthetic greenhouse gas emissions.

Sutin KM, Jain S, Gajic ZZ, et al. · 11 facilities · 148,762 anesthetics · DOI: 10.1213/ANE.0000000000008319
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At a glance

The study assessed the association of system-level changes with anesthetic emissions across NYC Health + Hospitals. Its central insight: emissions from nitrous oxide infrastructure may substantially exceed those from clinical delivery at an individual hospital.

94.6%
Estimated central N₂O supply lost before patient delivery at Bellevue
1.67
kg CO₂e/h lower N₂O-attributable emission rate associated with complete pipeline deactivation (Model 3)
148,762
General anesthetics analyzed across 11 facilities over 45 months

Research question

What were the relative contributions of central N₂O pipeline deactivation, decision-support alerts, and secular practice trends to reductions in anesthetic greenhouse gas emissions?

Why it matters

Deactivating central N₂O supply can address leakage upstream of the patient while selected locations retain cylinder-based access. Behavioral interventions address a different part of the emissions pathway.

Interpretation matters: Model 3 found a significant N₂O-specific association (P < .001). In the primary model for total hourly emissions, central pipeline availability was not statistically significant (P = .069). This was an observational study, not a randomized trial.

Methods & interventions

11
NYC Health + Hospitals facilities
45
Months, April 2022–December 2025
3
Hospitals deactivating central N₂O pipelines
Original Figure 1, study flow and intervention timeline

Interrupted time-series design

The study examined a staged clinical decision support advisory, staggered central N₂O pipeline deactivation, and broader practice changes.

Cylinder-based N₂O remained available in 37 of 73 anesthetizing locations (51%) at the three deactivation hospitals.

Figure 1 reproduced from Sutin et al., 2026, p. 4.

What was measured?

Case-level fresh gas flow, volatile and N₂O use, and derived emission rates expressed as kilograms CO₂-equivalent per hour of fresh gas flow time. Group-level monthly outcomes were analyzed using segmented regression.

Important exclusions

General anesthetics with total intravenous anesthesia alone, and missing or implausible data, were excluded. Outcomes therefore describe the analyzed inhalational anesthesia cases.

Compare the evidence

These outcomes are not interchangeable. Select an intervention to inspect its model, endpoint, and interpretation.

Baseline agent emissions

AnestheticCases using agentMedian hourly CO₂e rate when usedAnnualized CO₂e impact
Sevoflurane97.8%3.7 kg/h361 metric tons/year
Nitrous oxide27.2%9.3 kg/h360 metric tons/year
Desflurane2.3%30.3 kg/h88 metric tons/year

Values from the original baseline table, PDF page 6. Case percentages overlap in multiagent anesthetics. Annualized figures describe clinical gases, not upstream central pipeline losses.

At Bellevue, a separate procurement-based estimate indicated approximately 2,136 metric tons CO₂e/year from upstream N₂O losses. These data were not available for all hospitals.

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